![]() David acquired and managed a suite of research society-owned journals with OUP, and before that was the Executive Editor for Cold Spring Harbor Laboratory Press, where he created and edited new science books and journals, along with serving as a journal Editor-in-Chief. He oversaw journal policy across OUP’s journals program, drove technological innovation, and served as an information officer. Previously, David was the Editorial Director, Journals Policy for Oxford University Press. These are great starting points, and I highly recommend Glass’ book, now in its second edition, if you want to dig deeper and understand the nuances of the different types of negative and positive controls, not to mention method and reagent controls, subject controls, assumption controls and experimentalist Crotty is a Senior Consultant at Clarke & Esposito, a boutique management consulting firm focused on strategic issues related to professional and academic publishing and information services. These short videos offer quick lessons in positive and negative controls, as well as how to validate your experimental system. Novartis’ David Glass has put together the videos below, showing some of the basics of experimental validation and controls (Full disclosure: I was an editor on the first edition of David’s book on experimental design). Inadequate controls are often performed which fail to eliminate the effects of confounding factors, leaving the causality of any effect seen to be undetermined. This is often why so many bibliometric studies of the research literature are so problematic. This goes beyond science - controls are necessary for any sort of experimental testing, no matter the subject area. It’s how we know an experiment is testing the thing it claims to be testing. Controls allow the experimenter to minimize the effects of factors other than the one being tested. In my opinion, not enough time and effort is devoted to understanding the philosophy and methods of experimental design.Īn experiment without the proper controls is meaningless. Much of the training that scientists receive in graduate school is experiential, you learn how to do an experiment by working in a laboratory and performing experiments.
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